X Close

The painful truth about assisted suicide Lethal drugs don't promise dignified deaths

'Do not reanimate, I am 91+' Michel Porro/Getty Images

'Do not reanimate, I am 91+' Michel Porro/Getty Images


November 13, 2024   5 mins

There is a popular image of assisted suicide: a swift, straightforward procedure, backed by the awesome authority of modern science, sure to send you off in a comfortable doze. Dignity in Dying, for instance, claim that assisted suicide can “guarantee” a calm and peaceful death. Terry Pratchett expressed his wish to die “sitting in a chair in my own garden with a glass of brandy in my hand and Thomas Tallis on the iPod”.

Now compare the experience of Linda van Zandt. In 2016, on the day of her aunt’s assisted suicide in California, an Uber arrived bearing thousands of dollars worth of lethal medication. That included 100 capsules which had to be crushed, dissolved and swallowed within the hour. Wearing latex gloves and wielding toothpicks, the family frantically scraped the white powder from the capsules, combining it with a sugar syrup to make a bitter sludge so “vile” that van Zandt broke down in tears. Afterwards, she sat at her kitchen table wondering: “Who wrote this law?”

That, to be clear, isn’t everyone’s experience — but then nor is the romanticised picture presented by assisted-suicide advocates. The vision of people like Pratchett “is not the clinical reality”, says Mark Taubert, palliative care consultant and professor of medicine at Cardiff University. Claud Regnard, a retired consultant, points out that only two studies have compared “quality of death” by assisted suicide and by nature taking its course. Both studies, one in Oregon, one in the Netherlands, concluded that they were as good, or bad, as each other.

Assisted suicide relies on lethal drugs. But how reliable are the medications themselves? An article in a leading medical law journal remarks: “The pervasive belief that these, or any, noxious drugs are guaranteed to provide for a peaceful and painless death must be dispelled; modern medicine cannot yet achieve this.” On every point — the supply chain, the means of administration, the risk of complications — the reality is far from straightforward. But that reality is about to hit Britain as the Leadbeater Bill on assisted tying is being debated by MPs on 29 November.

Take Mehdi Alavi’s Dream Pharma — which operated out of the Elgone Driving Academy in Acton. In 2011, this one-man firm was suddenly placed under the spotlight of an international human rights story, as it emerged that it was supplying Arizona’s death penalty system with deadly chemicals.

Why did Arizona have to rely on a man at a driving school in Acton? Welcome to the strange world of lethal drugs, a shadow world largely unmonitored by health authorities, where supply chains can suddenly disappear, where new experimental mixtures come and go, and where best practice remains decidedly unclear.

When it comes to the physical stuff doctors depend on, assisted suicide and the death penalty are entwined. In the early 2010s, European companies launched tough new restrictions on the export of certain drugs to the US because the drugs were being used for capital punishment. That explains the emergence of individual suppliers such as Mehdi Alavi. But these small-scale alternatives were soon banned by American courts too. US pharma companies also stopped making the drugs used in assisted suicide — possibly because there are few other medical uses for them.

“US pharma companies also stopped making the drugs used in assisted suicide — possibly because there are few other medical uses for them.”

The shortage caused problems for penitentiaries and assisted-suicide clinics alike. One chemical, until then a popular choice in assisted-suicide states, practically disappeared from the market. Assisted-suicide doctors’ groups scoured America looking for the drug, but to no avail. Next they turned to another chemical which was supplied by a company called Valeant. The company was plagued by scandal and investigated for price gouging; the price of the drug rose from around $400 to almost $3,000 per lethal dose between 2010 and 2016.

In the end, American assisted-suicide doctors had to come up with their own solutions. But the blend of toxic substances caused “severe pain” , so physicians tried out other combinations, tweaking the formula half-a-dozen times. Across the globe, meanwhile, there are countless variations: more than 30 chemicals are used in the different forms of oral or intravenous assisted suicide.

As with death penalty procedures, then, there is no gold standard, but rather a great variety of options, none of which has established itself as the most appropriate. According to an article in The Lancet, complication rates with assisted suicide may be even more frequent than those with the death penalty.

How serious are those complications? The data is extremely patchy, but some have attempted statistical estimates. With oral methods, a third of assisted suicides take between 90 minutes and 30 hours. Up to 9% have trouble swallowing the dose; up to 10% vomit it up; up to 2% re-emerge from their coma. There are also horror stories, such as the Dutch woman with Alzheimer’s who recovered consciousness and was held down by her daughter and husband while a doctor finally euthanised her.

Then there are the unknowns. Baroness Finlay, a palliative care specialist, told the parliamentary committee on assisted suicide last year that during executions by lethal injection, “four-fifths probably regained a degree of consciousness”. Finlay said that though there is an obvious need for more research on consciousness in euthanasia and assisted suicide, nobody has ever done a proper study.

Not everyone is so sceptical. As Silvan Luley of Dignitas has claimed: “There has been not one case that did not work, in the sense of the person not reaching the goal in a dignified way.” Dr Lonny Shavelson, of Bay Area End of Life Options, has made similar claims. “These,” he says, “are lovely deaths.”

But every claim and counterclaim should be qualified by the fundamental point: the evidence base is inadequate. No drug regulatory authority anywhere has approved any drugs for use in assisted suicide. The 2019 protocol from the Canadian Association of MAiD Assessors and Providers acknowledged that there had been “little to no research” on their recommended combinations, and “no peer-reviewed literature to guide best practice”.

In the British context, meanwhile, supporters of assisted suicide seem conscious of the need for more research. Dignity in Dying told me in a statement that assisted-suicide drugs “are under constant review amongst clinicians and that best practice is constantly developing”, and that the UK procedure would depend on “engagement with healthcare bodies and regulators”, drawing on other jurisdictions “where they are confident that the drugs used are safe, effective and provide dying people with a dignified death”.

Which drugs might a future UK assisted suicide programme adopt? The Leadbeater Bill mentions none specifically, simply stating that the “Secretary of State must, by regulations, specify one or more drugs or other substances”. Leadbeater has not given any view on the subject; her chief of staff Lance Price tells me that it would be a matter for NICE and other regulators. NICE didn’t respond to a request for comment. For their part, UK doctors themselves seem unaware of the challenges. As a 2016 report by the British Medical Association found, some physicians were “surprised” to learn that assisted suicide could come with complications.

Dr Regnard, who is not against assisted dying per se told me that the introduction of such unevidenced drug combinations would be completely unprecedented. “I think it puts us back 100 years to when there was no regulation, basically people could do pretty well what they wanted.”

In the end, the assisted suicide debate will hinge less on these questions, though, and more on the familiar trade-offs between personal autonomy and threats to the vulnerable. Yet that shadow world of lethal drugs suggests a broader point: that taking life is, at the very least, an awkward fit with healthcare — and that when these cocktails are introduced into a medical system, the system itself inevitably changes. You can call Kim Leadbeater’s proposal brave or reckless. But it would surely be the biggest experiment ever conducted on the NHS.

You can call Samaritans for free on 116 123, email them at [email protected], or visit www.samaritans.org to find your nearest branch.


Dan Hitchens writes the newsletter ‘The Pineapple’ and is former editor of the Catholic Herald

ddhitchens

Subscribe
Notify of
guest

51 Comments
Most Voted
Newest Oldest
Inline Feedbacks
View all comments
Seb Dakin
Seb Dakin
1 day ago

Without commenting at all on the pros and cons of Assisted Suicide, it does seem like nonsense to me to claim that there are no drugs available that can deliver a painless death.
Even before fentanyl, there was heroin. And there are drugs to knock you out for operations.
There are serious discussions to be had about Assisted Suicide, but a pharmaceutical or technological inability to achieve it is absolutely not an issue.

Paddy Taylor
Paddy Taylor
1 day ago

Personally, I could probably be persuaded to support the idea of assisted suicide for the terminally ill who are in pain and want to go with some dignity at a time of their own choosing. But when looking at the unforseen consequences in countries where it has been legalised, we should be very wary indeed. The process should never become easy, and certainly should not ever be considered commonplace
Canada legalised assisted dying in 2016 – initially only for the terminally ill. In 2021 that was extended to those with a chronic physical condition. Canada now has some of the world’s most permissive euthanasia laws, allowing all adults to seek medically-assisted suicide if they choose.
In 2022, more than 14 THOUSAND people availed themselves of this new legislation – that’s over 4% of all deaths in Canada that year. It is one thing for the law to permit the withdrawal of life support in the face of agonizing pain. But Canada instituted a system that allows people to choose doctor-assisted death for depression and other mental health issues, simple old age and even, most controversially, financial worries.
More sinister still was an advert on Canadian TV extolling not merely the morality but “the beauty” of assisted suicide, as though the policy is virtuous enough to be in line with the “brand values” the company wishes to promote.
(It won’t let me link to the ad – but it’s on YouTube. Search for Assisted Suicide Promoted by Canadian Retailer Simons – if it doesn’t terrify you, I’d be shocked)
Imagine, say, a John Lewis advertisement that reassured you that they are on your side, that they understand how difficult the cost of living crisis is for their customers, and that if only Granny would forego her expensive medical care and agree to being pushed off her perch then the rest of the family could get that lovely new sofa in the January sales, not to mention freeing up a house for the kids to sell.
We’re not quite there, yet – but this is where it starts. Normalising assisted suicide is the first step to pressuring people that it’s the responsible choice to take. If anyone had suggested just a few years ago corporations advertising their support for euthanasia, it would have seemed the stuff of dystopian sci-fi. Perhaps the scariest thing is just how readily believable such a practice is now.
Which celebrity would be shameless enough to front such a campaign, I wonder? Now that the BBC has finally tired of that grinning Toby-jug of woke, St Gary might do it. ……
“Dignitas. Because …. why be a burden?”

Hilary Easton
Hilary Easton
13 hours ago
Reply to  Paddy Taylor

I was in favour of assisted suicide until I saw a documentary by a disabled British actress. In Canada, poverty and homelessness are now legitimate qualifications for state suicide.

Then there is the uncomfortably honest words of Wes Streeting that with three current state of palliative care in this country, it could not be a fair choice. He should know.

Billy Bob
Billy Bob
12 hours ago
Reply to  Paddy Taylor

You say that 4% of deaths in Canada are now assisted suicide, yet you you don’t say how many of those people were terminally ill and would have been dead within a year anyway.
Without that info the statistic is rather meaningless

Gareth Rees
Gareth Rees
1 day ago

Every day in the UK there are tens of thousands of operations performed that require the client to be placed under a general anaesthetic. The process after inserting a canula into the back of the hand takes less than 10 seconds. If a professional clinician is incapable of then facilitating the delivery of KCl to stop the heart, for example, then they should be struck off for incompetence.

Mark O'Neill
Mark O'Neill
19 hours ago
Reply to  Gareth Rees

Gareth, the problem is that the patient would only *probably* die.

MBP Phillips
MBP Phillips
16 hours ago
Reply to  Gareth Rees

If that is the case why are there so many “botched” lethal injections in the US when the condemned man does not die easily?

Billy Bob
Billy Bob
12 hours ago
Reply to  MBP Phillips

Because doctors refuse to carry out lethal injections for execution, meaning they’re having to be done by people not trained to do so.
Many pharmaceutical companies also refuse to sell prisons the drugs needed to carry out the execution, so they often improvise with random cocktails of the drugs that they’re able to get they’re hands on

Claire Lessore
Claire Lessore
15 hours ago
Reply to  Gareth Rees

The Bill currently before Parliament requires the patient to SELF-ADMINISTER the lethal dose. Difficult to see how they can manage that after being fully sedated.

Jeanie K
Jeanie K
14 hours ago
Reply to  Claire Lessore

In that case is it not badly named to be debated as “Assisted dying”?

Douglas Redmayne
Douglas Redmayne
21 hours ago

This is about choice. Mind your own business.

Brett H
Brett H
19 hours ago

It might be simply about choice to you, but to others it’s much more.

William Amos
William Amos
17 hours ago

One can neither ‘choose’ to die or ‘choose’ to live.
One can only damage the physical body, with bare bodkin or poison, up to and only up to the farthermost rung of this mortal coil. Death is not an event in life, as the philosopher once said.
As it stands, self harm in almost every other context is rightly legislated against.
The question is a substantive one, it cannot be conjured away.
So its not quite as simple as an appeal to ‘choice’.

c hutchinson
c hutchinson
15 hours ago

My body, My choice.

Alex Lekas
Alex Lekas
16 hours ago

We are capable of putting people under anesthesia for surgery. We are capable of putting down animals with no apparent discomfort to them. But it’s somehow impossible to have a formula that works to stop the human heart? I’m a bit skeptical.

Andrew Wise
Andrew Wise
14 hours ago
Reply to  Alex Lekas

Try a Brompton Cocktail, tried & tested on royalty I believe

Hilary Easton
Hilary Easton
13 hours ago

In the eighties I had several friends who managed to die quite easily, by mistake, with heroin or morphine. Surely this is the drug of choice for a painless death.

J Bryant
J Bryant
1 day ago

The huge victory obtained by those opposed to assisted suicide is banning of direct, instantaneously effective means of assisted suicide as “cruel.” If a person wants to die instantly, and doesn’t have the physical ability, or emotional resolve, to do the job themselves, they should be able to ask another person to shoot them in the head, and the law should permit that option.
No doubt this comment will attract many downvotes. But I say if a person is truly committed to dying, a bullet (or two) to the brain is quick and as close to foolproof as you can get.
Of course, opponents will brand my suggestion “barbaric” etc. But is it really preferable to subject people to injection with noxious chemicals that might not work?

AC Harper
AC Harper
19 hours ago
Reply to  J Bryant

And you can make the grisly argument that some people, determined to kill themselves, are willing to involve or kill others, without their permission, by jumping off motorway bridges or train platforms.

Derek Smith
Derek Smith
17 hours ago
Reply to  J Bryant

It’s not a very ‘dignified’ way to go though, is it?

A guillotine would be better.

Claire Lessore
Claire Lessore
15 hours ago
Reply to  J Bryant

If someone else is pulling the trigger, that is not suicide any more (even ‘assisted’); that’s murder.

Hilary Easton
Hilary Easton
13 hours ago
Reply to  J Bryant

There is always the choice to stop eating, of course.

Martin M
Martin M
1 day ago

It seems strange that vets put down animals with no problems every day, but the author would have us believe that the same cannot be done for humans.

Brett H
Brett H
19 hours ago
Reply to  Martin M

Interesting point, but do we actually know about the perceived thoroughness of putting down animals.

Peter B
Peter B
19 hours ago
Reply to  Martin M

Quite. And no doubt many of the opponents of assisted dying are quite happy to have their pets put to sleep.
This is classic “problem selling” behaviour. Just throwing out FUD with no attempt to actually find solutions. Which, as you say, are known to exist.

UnHerd Reader
UnHerd Reader
18 hours ago
Reply to  Martin M

Strange you see no difference?

Lancashire Lad
Lancashire Lad
14 hours ago
Reply to  UnHerd Reader

The article suggests there’s a problem with ‘methodology’.
The point about having pets humanely put down is it demonstrates there is no problem with methodology. Strange that you’ve chosen to use a different idea – i.e. human v animal, to try to distort the very point the article is based upon.

Lancashire Lad
Lancashire Lad
18 hours ago
Reply to  Martin M

One look at who he writes for in the footnotes tells us all we need to.know.

Alan Tonkyn
Alan Tonkyn
14 hours ago
Reply to  Lancashire Lad

No, it doesn’t. The fact that he has written for a Catholic paper doesn’t invalidate the points he’s making. Deal with those, rather than making a superficial ad hominem comment.

Lancashire Lad
Lancashire Lad
13 hours ago
Reply to  Alan Tonkyn

The superficiality exists entirely within the article itself, which is disingenuous, and for reasons i’ve suggested elsewhere.

In terms of “ad hominem” the author is very much culpable of that in respect of seeking to undermine the dignity of those suffering from terminal illness and their loved ones.

Alex Lekas
Alex Lekas
16 hours ago
Reply to  Martin M

I had the same thought.

William Amos
William Amos
14 hours ago
Reply to  Martin M

Interesting thought.
Perhaps in future the idea of a natural death will be as remote and terrifying for the well conditioned model citizen as a ‘natural birth’ is now.
Still better it will be presented as ‘reckless’ and ‘selfish’ when the State is willing o manage it all for us.

Billy Bob
Billy Bob
11 hours ago
Reply to  Martin M

It sounds as if the first example in the article bought the assisted suicide kit from Temu

Peter Johnson
Peter Johnson
1 day ago

Given that Health Authorities have merrily carried out gruesome experiments with drugs and surgeries on ‘trans’ youth with frequent disastrous outcomes – the complete lack of evidence supporting these procedures isn’t really shocking at all.

Brett H
Brett H
1 day ago

Mmm, looks as if, once again, the authorities have not given us the whole truth. What a surprise. But why? Why has the information been so vague or misleading?

Andrew Roman
Andrew Roman
23 hours ago

There is a fundamental difference between the US law and Canadian law. US law requires self-administration by the patient, at the patient’s expense. Canadian law permits the physician to administer first an anaesthetic medication to put the patient to sleep and then the lethal injection to stop the heart. The cost to the patient is zero because it is covered by Medicare. The procedure is usually performed with family and friends present.

Hilary Easton
Hilary Easton
13 hours ago
Reply to  Andrew Roman

Two words: slippery slope. The Canadian law didn’t start out that way, once the principle is established it the qualifying criteria are easily expanded.

Stuart Sutherland
Stuart Sutherland
22 hours ago

Surely the quickest way to kill someone would be a bullet into the brain. Messy but quick!

Ben Scott
Ben Scott
18 hours ago

Guillotine!

Citizen Diversity
Citizen Diversity
20 hours ago

One of the proponents of this Bill has described assisted dying as ‘shortening death’.
Wasn’t that where Jesus of Nazareth rose from the dead on the third day. Even Jacob Marley was only dead to begin with.

AC Harper
AC Harper
19 hours ago

To the State taking a life is easy and unremarkable. Deny people adequate heating or food and they will die. It may take some time but, miraculously, the State’s hands remain clean.

sal b dyer
sal b dyer
18 hours ago

Palliative Care is pretty good these days. Most people with terminal illnesses have a relatively pain free death in surroundings of their choosing. More of a problem is dementia. No one with dementia is going to ask for an assisted death because they don’t understand what’s happening to them, almost by definition. Denial, delusions and paranoia are pathognomonic. The higher cognitive functions are the first to degenerate. So insight, judgement, decision making etc are impaired. Exactly the functions needed to consent to an assisted death. Just visit a “secure” psycho-geriatric unit, watch perplexed, agitated patients wandering around and around a sterile hospital ward smelling of urine, not recognising staff or family anymore. Experiences differ of course, but it often looks like a living hell. There appears to be no enjoyment of life at all. The idea of ending life like that is unbearable. But an increasing percentage of us will succumb to dementia because we’re not dying from heart disease, strokes and cancers like we used to. Not only that, but demented patients are living longer due to improved care. They are shielded from harm, fed and cleaned well, and not “chemically restrained” ie not sedated, so they get to experience the full force of their persecutory delusions. I wish I could leave a living will asking for an assisted death in the event of a dementia diagnosis. But no one will agree to it because the very mechanism of the disease will preclude informed consent at the time. In fact it’s likely to be aggressively opposed by the person who may have actively wished for it just a few months earlier. It’s a conundrum that no assisted dying authorities have addressed. Interested to hear other people’s views.

William Amos
William Amos
14 hours ago
Reply to  sal b dyer

This is the interesting ‘other side’ of the conversation and you put your points well.
Choice, consent, life, death. Shakespeare made a sonnet cycle out of these themes which still baffles the intelligent reader.
“To this I witness call the fools of time,
Which die for goodness, who have liv’d for crime”
The artificial extension of life beyond the seeming natural point of human continence and into that vale of “labour and sorrow” which attends advanced senesence must also be borne in mind.
Consent as well, as you mention, is another vexed question. It appears to be the last shared juridicial standard in our society and yet it is so very frail.
Can the present ‘Will’ bind the future? Trammel up the consequence and leap the world to come? “Regret, like an April Violet” is just as real as the will to consent, just as true – and how can we possibly know if a suicide regrets?

Sue Sims
Sue Sims
16 hours ago

Most of the comments here confuse ‘assisted dying’ with ‘euthanasia’. The former is actually assisted suicide: the patient administers it himself. The latter is permitted killing by a second party, generally a doctor. The difference is important. Almost all commenters here are talking about euthanasia, comparing it to anaesthesia or ‘putting to sleep’ pet dogs and cats, and focusing on the probably lack of pain. But Kim Leadbetter is trying to introduce assisted suicide, and specifically excludes euthanasia in her bill.

Andrew Wise
Andrew Wise
14 hours ago
Reply to  Sue Sims

The difference is important but I don’t see how it impacts the choice of drugs used.

MBP Phillips
MBP Phillips
16 hours ago

Not true re vets. In the last three years I have had to have two dogs put down. In each case it was an horrific procedure. In one the vet tried to get the canule into all 4 legs. Before he managed the dog was screaming in pain. In the other, similarly, the vet’s assistant insisted on stretching out the paw of a dog which was in severe arthritic pain causing it even more pain.

Huub B
Huub B
14 hours ago

Any anesthesiologist can tell you how patients should be put into deep sleep, with the inability to breathe, and on top of that, what substances should be injected to stop the heart. That it is handled so frenetically in the USA is a shortcoming, from which many people will suffer. It is purely a lack of legal options.

Andrew Wise
Andrew Wise
14 hours ago

But it would surely be the biggest experiment ever conducted on the NHS.

oh really? And the whole Covid fiasco wasn’t?

Lindsay S
Lindsay S
12 hours ago
Reply to  Andrew Wise

I remember when pharmaceutical companies had to pay to experiment on people, now the NHS pays them!

Jeanie K
Jeanie K
14 hours ago

What an evil country this country has become since she gave up Christianity.

Lancashire Lad
Lancashire Lad
12 hours ago
Reply to  Jeanie K

Did you ever hear about the 17th & 18th century witch trials, torture and murder, all.in the name of Christianity?