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June 8, 2024 - 5:30pm
“Welcome to the Psychedelic Twenties!” announced Rick Doblin, dressed in an all-white suit. He was speaking last June at the Psychedelic Science conference in Denver, sponsored by the organisation he founded, the Multidisciplinary Association for Psychedelic Studies (MAPS). That was nearly a year ago. Now, he finds himself fighting for his life’s work.
Doblin has long been at the forefront of the “psychedelic renaissance”, pioneering a series of studies seemingly showing the potential of MDMA, or ecstasy, to treat post-traumatic stress disorder (PTSD). though his New Age approach has provoked some scepticism. Earlier this week, however, the advisory board of the United States Food and Drug Administration (FDA) voted 10-1 against approving MDMA as a medicine, dashing the hopes of ravers and therapists alike.
We’ve been here before. Therapists used psychedelics in the Fifties, and it was only the backlash to the trippy-hippy counterculture that got them banned in the following decades. But the FDA’s decision is still significant for the future of MDMA. As shares for companies investing in such medicines plummet, could this be the end of the psychedelic renaissance?
When Doblin founded MAPS in 1986, MDMA-assisted therapy was supposed to be a Trojan horse for mainstreaming other psychedelics. “MDMA is a tool, and it can be used in many different ways,” Doblin told me last year. “The two-part strategy we have is drug development and drug legalisation and regulation: it should be legal for everybody. It’s very important to keep in mind that our fears of the exaggerated risks of these drugs and the counterproductive drug war have come at enormous cost. And when we think about costs, we almost never think about the things that didn’t happen: millions of people could have had phenomenal experiences on the dance floor, and hundreds of thousands of suicides could have potentially been prevented.”
As ecstasy, the drug’s euphoric properties are of interest to therapists helping patients face their fears without being overwhelmed: 71% of trial test subjects no longer met the criteria for PTSD at the end of the most recent study run last year by MAPS. But the FDA took issue with the experiments’ lack of “blinding” — because of MDMA’s intense psychoactive effects, it would be difficult for a control group to not know they’d received a dud — and alleged ignoring of serious side effects.
“I believe in the therapeutic potential of MDMA, and I used to be a MAPS supporter and volunteer,” Neşe Devenot, a senior lecturer at Johns Hopkins University, told me. “Over time, however, I noticed a distinct pattern of MAPS leaders covering up harms and lying at the expense of victims.” She added: “This clearly conflicted with their claim to having the answer to trauma. I have experienced the benefits of psychedelics firsthand, and psychedelics deserve to be the focus of rigorous research. I hope that this is a wake-up call for the field to pay attention to the quality of its research and the integrity of its behaviour.”
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SubscribeI have a hard time thinking what America needs is more drugs. Pot use is soaring, with a slew of negative effects, especially for teens. 20% of people are taking psychoactive drugs. Yet, mental health is worse than it’s ever been. We have record suicides, and 100,000 over dose deaths a year.
Maybe a spot of ecstasy would cheer the nation up a bit then?
It always did me, until the next morning anyway
8 shots of whiskey will do the same. Until the morning. Which is the whole point.
Do both. Now that would be a night to remember!
I used to do drug development for a living (and by “drug” I mean molecules that treat diseases, not recreational drugs that provide some sort of high). I’m open to the use of strongly psychoactive drugs to treat diseases otherwise resistant to treatment. For example, the active ingredient in marijuana has been shown to significantly (sometimes profoundly) reduce the severity of Crohns Disease (and other inflammatory diseases of the gut) in some treatment-resistant patients, especially in young people.
I don’t regard these molecules as curealls. They should be approved for limited use in otherwise treatment-resistant patients. I hate to see them banned completely for political reasons.
Unfortunately, to date, psychoactive drugs have been mostly used to treat restlessness in teen boys, and sadness in teen and early 20’s men and women. In other words to treat life, not a disease.
Alcohol can have negative effects too, but nobody has a problem with that.
Anyone with a family member having a medical problem that is difficult to treat, will surely hope the medical community will not be prevented from evaluating ALL drugs for possible beneficial properties. And I feel any patient who wishes to use ANY drug they feel may benefit them, should not be prevented from doing so.
This is an an absolutely vacuous statement.
Maybe explain why you think it is, rather than slinging mud?
Oh the irony.
The author is a former drug dealer.
When laudanum was developed it was purported to be a psychiatric cure-all. Then anti-psychotics. Then benzos. Then tricyclics. Then SSRI’s. Then…
If folks haven’t figured it out by now, our mental health crisis is existential. It’s not from a deficiency of the right drug to treat those who are increasingly disconnected, disenfranchised, and depressed.
The solution to this crisis is not going to be found at the bottom of an empty pill bottle.
Exactly. You have to find meaning in something. God, country, family, friends, career. Otherwise life is a hollow slog.
Both things can be true at the same time – and in this case they are. This is well understood – in 40 years of working the menal health, I’ve not come across a single professional who thought that pills are a solution. Back on to the subject at hand – many, I’d guess millions, have realised profound truths under MDMA/LSD/Psilocybin. Experiences that helped them turn their life around, or deepen their apprecation – starting with figures such as Aldous Huxley, Cary Grant, Richard Alpert, Ken Kesey. Unfortunately, the power of such drugs became unharnessed in the TIm Leary period, and a reactionary Niixon White House banned them totally. Funny to think that Nixon, and the ‘government elite/blob’ claimed Leary to be the most dangerous man in the USA, the greatest threat to young people; whilst simultaneously sending tens of thousands of young Americans to their graves in a war which did tremendous damage to America’s confidence and standing, right up to the present day – a national disaster second only to Jim Crow.
Most people aren’t going to find it in a church either. In earlier more superstitious times perhaps, but not now.
We in Australia are making progress in this area, as the article states. Progress can be made in different countries at different times. Australia is more advanced than the US in medical use of MDMA, whereas the US is more advanced than Australia in the legalisation of cannabis.
It would help if the lead scientists researching these effects weren’t, so often, past or current casual users. It provides easy criticism of conflicts of interest bias.
I’m not sure why that makes a difference. The use of such substances medically is quite different to recreational use.