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Ukraine’s new cure for the horrors of war: Ketamine and MDMA Drugs could make men better warriors

'To Fathom Hell or Soar Angelic, just take a pinch of psychedelic.' Bulent Kilic/AFP/Getty Images

'To Fathom Hell or Soar Angelic, just take a pinch of psychedelic.' Bulent Kilic/AFP/Getty Images


February 15, 2024   4 mins

Can ketamine and MDMA help Ukrainian soldiers cope with the horrors of war? Given the urgent nationwide mental-health crisis, the Ukrainian government is warming to the radical idea. And some army units are already experimenting. The nation could soon find itself on the front line of a global drug therapy revolution.

So far, Dr Vladislav Matrenitsky, a pioneer of psychedelic-assisted psychotherapy based in Kyiv, has treated around 300 patients suffering from depression, PTSD, or anxiety with ketamine therapy. A growing number of them have been soldiers, including a military psychologist, Ihor Kholodilo, who was left unable to speak after his jeep was hit by a Russian tank shell. After six sessions of ketamine therapy, his stammer was cured. Since then, he claims to have referred an elite Ukrainian special-forces unit for the treatment.

Though using ketamine to treat mental illness has been legal in Ukraine since 2017, MDMA and psilocybin — the active molecule in magic mushrooms — are still banned. But Kseniya Vozsnityna, director of Forest Glade, a government military-rehabilitation centre, believes that a pilot project using MDMA and psilocybin could be approved within six months. If so, Ukraine would be in good company. Australian clinicians became the first to treat patients with MDMA and psilocybin at the start of this year, while MDMA-assisted therapy could become a treatment for PTSD in the US this year, with the Food and Drug Administration in the final stages of approval.

As a researcher in the field, and having run legal psilocybin retreats, I’ve seen first-hand how careful use of psychedelics can help people with life-long depression or crippling PTSD. And when I spoke to psychiatrist and psychedelic researcher Simon Ruffell, he said that his ongoing study giving combat veterans Ayahuasca in Shipibo ceremonies in Peru is showing promising results: of the 28 participants with PTSD, none met the study’s criteria for PTSD after treatment.

Yet psychedelic therapy is a complicated process. An experience with psilocybin or MDMA might last eight hours, often with two therapists present for a single participant. During the trip, participants might come face to face with memories, feelings or thoughts from which they had disconnected and work through them; or they might have a powerful “mystical-type experience”. After the trip, they are encouraged to make sense of the profound insights and realisations they’ve had and integrate them into their life in a meaningful way.

In a war zone, however, drug therapy raises complex ethical questions. For instance, should ketamine or MDMA be used to improve performance in battle? Kholodilo argues that not only would psychedelics stop depression spreading through the trenches, but it could also help frontline soldiers overcome their paralysing fear of death. The appeal of this isn’t hard to glean. As Oleh Orlov, chair of the Ukrainian Psychedelic Research Association, told me: “We are in the middle of a huge war, so we kind of need people recovered. We don’t have the luxury to just go home and recover.”

“Should ketamine or MDMA be used to improve performance in battle?”

It wouldn’t be the first time that psychedelics have been considered for use in warfare. In the paranoid climate of the Cold War, the CIA grew obsessed with the idea that LSD could help with espionage and psychological warfare. Between 1953 and 1973, it carried out operation MK-Ultra, a secret and illicit human experimentation programme aimed at discovering new methods of mind control and interrogation. The full scope of this shameful operation was laid bare in 1974, when it emerged that the CIA had drugged unwitting citizens with LSD to see if it could be used to force confessions. The truth is, psychedelics are far too complex and unpredictable for these purposes, but that discovery came at the cost of broken minds and shattered lives.

That said, there is no evidence that Ukraine is planning to use psychedelics or ketamine for any other purpose than mental-health treatment. And Orlov hasn’t heard of anyone in the government or the clinical community promoting psychedelics for use in battle. His NGO is focused entirely on the spiralling veteran mental-health crisis — although he does view the introduction of psychedelic therapy for veterans as a matter of national security. Ruffell, meanwhile, is sceptical that drug therapy could be used to fortify Ukrainian warriors, telling me that most of the veterans he’s treated come out of their Ayahuasca experience looking for more peace in their lives, not a return to the front line.

But such treatments are still a long way off for most Ukrainians. And in desperation, many are starting to self-medicate. Dr Jack Allocca, a neuroscientist and pharmacologist at the University of Melbourne, went to Ukraine last summer to interview soldiers, clinicians, and Ukrainian civilians about medical and recreational drug use. He described a hedonistic and chaotic scene in Kyiv and Odessa, with Ukrainians “using partying as group therapy” and taking a wide variety of drugs. The black market has been flooded with the usual recreational drugs you’d find in most cities, as well as obscure psychedelic research chemicals. These include drugs in the DOx family, which are chemically related to MDMA but highly potent and more psychedelic, with a trip lasting for 48 hours. Allocca was surprised to see such drugs on the streets, and described it as a live experiment by drug cartels on a traumatised population.

The result of all this self-medication, Allocca says, is “very messy”. One person he interviewed was overcome with guilt and grief during his trip because he feared he was going to be drafted. Another who had managed to dodge the draft got stuck in a guilt-ridden thought-loop. This is hardly a healing experience. And it’s worth emphasising that, in order to be effective, psychedelics and ketamine have to be combined with a therapeutic practice. The psychedelic experience is highly contextual, and indigenous cultures that have used them constructively have always done so in combination with meaningful rituals that give the trip a wider purpose. It is important that we do this as well.

There is, however, a good chance that Ukraine will become a hub for psychedelic research in the coming years. According to Orlov, Ukraine’s drug enforcement agency isn’t averse to rescheduling psilocybin and MDMA in a medical context, though the Minister of Health has requested more clinical data. A local pharmaceutical company has offered to make MDMA for $10 per dose, far less than it costs in the US or UK, so that small Ukrainian trials may begin.

But in the fog of war, no one can be sure what the future will hold. After all, in a nation torn by violence, psychedelic therapy can both offer profound healing and, when used unchecked, lead to disorder. Humphry Osmond, who coined the phrase “psychedelic”, may have put it best when he wrote to Aldous Huxley in the Fifties: “To Fathom Hell or Soar Angelic, just take a pinch of psychedelic.”


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Matt Hindman
Matt Hindman
9 months ago

Anyone else find this disturbing?

George Locke
George Locke
9 months ago
Reply to  Matt Hindman

Yes. It is a bit Brave New World…

Martin M
Martin M
9 months ago
Reply to  Matt Hindman

We in the West take lots of drugs for all sorts of reasons. Some of that drug use produces desirable outcomes, some doesn’t. Why should Ukraine be any different?

Steve Farrell
Steve Farrell
9 months ago
Reply to  Matt Hindman

Yes. Very.

Arek Stryjski
Arek Stryjski
9 months ago
Reply to  Matt Hindman

No.
I hope the war will end soon. Then we will need both rebuild the country but also heal deeply traumatised society for them to fully join Europe.

I’m disturbed what nothing like this will be available in Russia and they will only go deeper into intergenerational trauma.

jane baker
jane baker
9 months ago
Reply to  Arek Stryjski

Blackrock + some other big American corporations are all signed up to move in and restore the infrastructure. Won’t Babushka have a surprise when they fix her roof but she gets home to find it’s now a 50 storey steel and glass tower block.

Ron Kean
Ron Kean
8 months ago
Reply to  jane baker

Yes. If you search for Grozny you’ll see before and after pictures (images) of the city. Russia destroyed part of it but now there are modern high rise apartment buildings.

Martin M
Martin M
9 months ago
Reply to  Arek Stryjski

Good point, but I for my part have difficulty feeling sorry for the Russians.

Sarah Bruckshaw
Sarah Bruckshaw
9 months ago
Reply to  Matt Hindman

No, not the use of ketamine assisted psychotherapy. From personal experience, it is a very effective therapy, and I can imagine it is a lifeline for soldiers suffering from PTSD.

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  Matt Hindman

No, not really I must confess.
If it improves morale so much the better.

Remember what the Corsican pygmy* said:-
“The moral is to the physical as three is to one”

(*Napoleon Bonaparte.)

Benedict Waterson
Benedict Waterson
9 months ago
Reply to  Matt Hindman

No, the idea that drugs must be taken with therapeutic guidance within a conceptual framework which gives them purpose is a good insight. The alternative is hedonistic drug culture, within an individualistic framework, which might have disturbing results.

Martin M
Martin M
9 months ago

The alternative is hedonistic drug culture, within an individualistic framework.
You say that as if it’s a bad thing.

Ron Kean
Ron Kean
8 months ago

‘Therapeutic guidance’ is the key to this kind of usage. People with experience should learn the effects of different dosages. Also verbal guidance is needed to make the experience pleasant and not cause a bummer or a bum trip as people used to say in the 60’s. Dosage is the biggest problem in street use. Too much hurts.

L Brady
L Brady
9 months ago
Reply to  Matt Hindman

No. These natural drugs have been proven to be effective for many years. I listen to scientists and look at the actual evidence on these issues – you’re not a scientist and have obviously based your opinion on prejudices.

Martin M
Martin M
9 months ago
Reply to  L Brady

Ketamine isn’t a “natural drug”.

Ted Ditchburn
Ted Ditchburn
9 months ago
Reply to  Matt Hindman

Not really. All wars for centuries, well forever really, have seen soldiers use mind-altering drugs and ‘performance enhancing’ drugs.

Ron Kean
Ron Kean
8 months ago
Reply to  Ted Ditchburn

I don’t know about all wars but it sure is different from the rum ration and an occasional bottle of french wine in World War I.

Jonathan Nash
Jonathan Nash
9 months ago

I thought it was well known that most of the Russian army are high as kites most of the time.

Kent Ausburn
Kent Ausburn
9 months ago
Reply to  Jonathan Nash

And their drug of choice being vodka, I suspect.

Charles Stanhope
Charles Stanhope
9 months ago

In the ‘good old days’ it was Rum that normally
did the trick.
The UK (really England) managed to conquer nearly 25% of the Globe with it.

N Satori
N Satori
9 months ago

Rum? Huh!
Back in the really old days, according to historian Barry Strauss, the Celtic women had their own method of instilling courage into their male warriors. They would form an armed line at the rear ready to slaughter any man seen running away from the enemy.

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  N Satori

The Romans saw off Boadicea/Boudicca without much trouble, although after a poor start it must be granted.

N Satori
N Satori
9 months ago

The Celts Barry Strauss referred to in particular were the European Celts who formed a large part of Spartacus’ rebel army. The Romans beat them too – also after a poor start.
While the Celtic warriors preferred a heroic battle, each man proving his courage even unto death – the ladies just love that! – the romans preferred machine like efficiency – just what you’d expect from a nation of engineers and builders.

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  N Satori

The Romans had a ‘system’; It helps!

Mike Downing
Mike Downing
9 months ago

I read ‘Blitzed’ by Norman Ohler about the mass use of drugs in the Third Reich despite the official condemnation of them as stimulants for the general population.

I think the main one was called Pervitin; a methamphetamine which allowed the troops to stay alert, focused and calm for days without any ill-effects. That’s how they managed to reach the Channel and almost surround the British before Dunkerque.

Hitler in the latter stages of the war was just a shell propped up with massive injections of all sorts of ‘therapeutic substances’ provided by his special physician.

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  Mike Downing

It wasn’t Pervitin that got the Wehrmacht to the Channel coast, but far better leadership combined with superlative tactics.
‘We’ were lucky that they let us “run away”!!!

comment image

Any guesses for what is going on here then?

Mike Downing
Mike Downing
9 months ago

Agreed Charles, but the Pervitin enabled them to carry on without a break or any sleep for 72 hours. After it was over, the Wehrmacht was photographed crashed out on their equipment like zombies (or indeed like today’s youngsters after a weekend long rave).

All the German forces were allocated Pervitin as part of their kit and required to take it before all major offensives. It helped them steady any nerves and gave them a feeling of euphoria and invincibility.

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  Mike Downing

I’m not denying the benefits of Pervitin but it can and HAS been done without it.

It is not to be advised if flying a Stuka or Messerschmitt, driving a Tank, firing a mortar of even a Spandau- 36, but for the basic ‘grunt’ business it certainly helps one keep going!!

ps. Any guess on the photo?

Mike Downing
Mike Downing
9 months ago

It looks like a scene of surrender on the French / Belgian coast?

Tom D
Tom D
9 months ago
Reply to  Mike Downing

Boulogne 1940?
But it might be photoshopped.

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  Tom D

Closer.
In fact it is St Valery-en-Caux, the 12th June 1940. The surrender of the the 51st Highland Division, commanded by the somewhat unfortunately named Major General Victor FORTUNE to Major General Erwin Rommel, commanding the 7th Panzer Division.

Perhaps the most humiliating day in Sc*tch military history since the catastrophe at Magersfontein some forty odd years before.

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  Mike Downing

Near.

Cathy Carron
Cathy Carron
9 months ago
Reply to  Mike Downing

There have been a few articles about Hamas’ use of drugs in its Oct 7 raid on Israel….

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  Cathy Carron

Hasheesh surely?

Ron Kean
Ron Kean
8 months ago
Reply to  Cathy Carron

Doctors that examined some hostages who were released say that some were given anti-depressants similar to valium to keep the more frightened ones quiet. Also a couple of Israeli security officials told USA Today some of the terrorists were high on Captagon that works like methamphetamines during the attack.

Tom D
Tom D
9 months ago
Reply to  Mike Downing

After the Battle of Ir Drang large amounts of syringes and heroin were found on the North Vietnamese casualties.
And we have the case of the Pakistani terrorists who attacked Mumbai: they injected themselves with meth and cocaine prior to the attack. Killing machines indeed.

Mike Downing
Mike Downing
9 months ago
Reply to  Tom D

Weren’t the US troops in Vietnam ‘off their tits’ (in the current parlance) on all sorts of illegal substances ?

Charles Stanhope
Charles Stanhope
9 months ago
Reply to  Mike Downing

They were, and as a result ‘fragged’/ killed about 1,000 of their own officers.
Not a good report.

Martin M
Martin M
9 months ago
Reply to  Tom D

Heroin is an odd thing to take before a battle….

Dumetrius
Dumetrius
9 months ago

Ummmm, one’s fellow soldiers, and civilians one meets, can die in a war.

Causing sadness.

Has anyone here ever taken ketamine when they were sad?

If you have, you’ll know instantly why this is not a good idea.

Alex Lekas
Alex Lekas
9 months ago

Good lord. It’s not enough to have a half-million dead Ukrainians and counting, plus the millions more who’ve fled never to return, the plan is to drug those remaining?

Nick Wade
Nick Wade
9 months ago

“ not only would psychedelics stop depression spreading through the trenches, but it could also help frontline soldiers overcome their paralysing fear of death…”

Aren’t people supposed to be afraid of death? It’s kind of where survival instinct comes from.

Martin M
Martin M
9 months ago
Reply to  Nick Wade

People generally are afraid of death, but it is unhelpful for soldiers to be so. The best aren’t.

Philip May
Philip May
9 months ago

Nothing new here.
Pervitin was used by Nazis during WW11 and the Allies used something as well.
Welcome to modernity.

UnHerd Reader
UnHerd Reader
9 months ago

I think it’s disgusting! Instead of medicating people go be ok about dying horribly, how about just not going to war? Or if it becomes necessary, then only long enough to agree a monitored cease fire.
I find this article morally abhorrent. Getting people to collude in their own death by feeding them drugs is appalling.
As for “curing or avoiding” PTSD, well of course it will, as it will completely override the brains system for recognising and avoiding life threatening situations.

Ron Kean
Ron Kean
8 months ago
Reply to  UnHerd Reader

John Lennon used to protest against war but he may have been on acid at the time.

jane baker
jane baker
9 months ago

Oh God. Are they drugging them up. Hey,watch Pavlo from Ukraine on his you tube channel. He ain’t in uniform. He’s a sly b*****d with his OnlyFans girlfriend/partner/wife/business partner.

William Brand
William Brand
9 months ago

In time of war, every soldier is a dead man walking. The war veterans are the kids that were enlisted on the last 6 months of the war and mostly never saw combat plus a few cripples from the earlier years of fighting. The start and middle of the war soldiers will never go home except in wheelchairs or coffins. They need to be drugged up to enable them to forget that their lives will be over within a few months at best.